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Papers accepted for publication

1. Collagen I and III, MMP-1 and TIMP-1 immunoexpression in dilated cardiomyopathy

Alexandru Radu Mihailovici, Ruxandra Camelia Deliu, Claudiu Margaritescu, Cristiana Eugenia Simionescu, Ionut Donoiu, Octavian Istratoaie, Diana Rodica Tudorascu, Elena-Anca Tartea, Dan Ionut Gheonea

The extracellular matrix (ECM) remodeling represents the pathological substrate of dilated cardiomyopathy (DCM). In this study, we statistically analyzed the immunoexpression of collagen I and III, matrix metalloproteinase-1 (MMP-1) and its tissue inhibitor-1 (TIMP-1) in the myocardial tissue in 18 cases of DCM compared to a control group. We observed a significant increase in the immunoexpression of collagen I and III in patients with DCM and a significant reduction in the immunoexpression of MMP-1 compared with the control group. Also, the collagen I and TIMP-1 expression indicated a positive linear correlation and respectively a negative linear relationship with collagen III and MMP-1. The analyzed markers in this study can be used to quantify the degree of collagen sclerosis from the ECM of DCM.

Corresponding author: Cristiana Eugenia Simionescu, Professor, MD, PhD; e-mail:

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2. Ethical dilemmas in communicating bad news following histopathology examination

Dan Alexandru Constantin, Ionut-Horia Cioriceanu, Marilena Monica Tantu, Daniela Popa, Dana Badau, Victoria Burtea, Gabriela Codruta Nemet, Liliana Marcela Rogozea

Purpose: The study proposes an analysis of the ethical aspects that occur in communicating bad news following histopathology laboratory tests in medical practice, in particular in the case of the anatomical pathology diagnosis confirming a medical condition of poor prognosis. Background: Over the last decades, the progress of science and technology in the medical field, as well as the explosive increase of specialist information available on the Internet have led to unprecedented ethical issues related to the communication modality of histopathology test results to patients. Content: The paper analyses from an ethical and legislative perspective the main ethical dilemmas that occur when choosing a modality for communicating test results. Discussion and Conclusions: While communicating bad news is an essential ability for medical professionals, it should be used within the context of observing the patients’ right to decide whether they wish to receive such information or not and their right to their own autonomy, by means of a personalized protocol for communicating bad news in current medical practice.

Corresponding author: Ionut-Horia Cioriceanu, MD, PhD Student; e-mail:

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